The 9th iHuman Forum

The 9th iHuman Forum

November 8th to 9th, 2024
Conference Center, ShanghaiTech University, Shanghai, China




November 8th to 9th, 2024
Conference Center, ShanghaiTech University, Shanghai, China




About the event

The 9th iHuman Forum, organized by the iHuman Institute at ShanghaiTech University, will be held at the ShanghaiTech University Conference Center from November 8 to 9, 2024.

Since its establishment, the iHuman Institute at ShanghaiTech University has successfully hosted the iHuman Forum eight times. This year's forum will focus on the theme AI-Driven Frontiers in Cell Signaling and Translational Research: Challenges and Opportunities, and will serve as one of the thematic forums of the 17th Pujiang Innovation Forum 2024. The 9th iHuman Forum covers three research topics: I. Membrane Protein Structure & Function, II. Target Mechanism & Drug Discovery, and III. In situ Structural Biology.

The forum will provide a high-level platform for showcasing and exchanging the latest advancements in the fields of structural biology, chemical biology, computational biology, medicinal chemistry, and cryo-electron tomography. We warmly invite scientists and researchers from various research institutions, universities, and industry to participate and contribute to the exploration and innovation in these areas.


Register

Program

Session I｜Membrane Protein Structure & Function｜Chairs: XU Fei & HUA Tian
November 8
9:00-9:10 Opening RemarksYIN JieShanghaiTech   University
9:10-9:15Photo
9:15-9:40Drug   Discovery Targeting G Protein-Coupled ReceptorsXIE   XinShanghai   Institute of Materia Medica, CAS
9:40-10:05Transport   mechanism and pharmacology of the human GlyT1ZHAO   YanInstitute   of Biophysics, CAS
10:05-10:20Coffee   Break
10:20-10:40The   molecular basis of opioid receptors activated by opioid drugsWANG   YueShanghai   Institute of Materia Medica, CAS
10:40-11:00Signal   transduction and functional modulation of metabotropic glutamate receptorsLIN   ShulingShanghai   Institute of Materia Medica, CAS
11:00-11:15Characterizing   the role of extracellular domain in GLP-1R biased agonismXIE   LinshanRaymond Stevens Lab,ShanghaiTech   University
11:15-11:30Balanced G protein and arrestin recruiting by the adenosine 2A receptor related to structural dynamics by genetic labeling and 19F-NMRGUO   Canyong Kurt Wüthrich Lab,ShanghaiTech   University
11:30-11:45Structural   basis of proton sensing and allosteric modulation of GPR4 and GPR65YUE   Xiaolei LIU Zhi-Jie Lab,ShanghaiTech   University
11:45-12:00Structural   basis of antagonist selectivity in endothelin receptorsLIU   ShenhuiHUA Tian Lab,ShanghaiTech   University
12:00-12:15Structural   and Pharmacological Studies of Mammalian TAAR1JIANG   KexinXU Fei Lab,ShanghaiTech   University
12:15-13:30Lunch   Break

Session II, Part 1｜Target Mechanism & Drug Discovery｜Chairs: SHUI Wenqing & ZHAO Suwen
November 8
13:30-13:55“It is the   theory which decides what we can observe”--Ras-Raf signalosome as an exampleSHAN   Yibing ShanghaiTech   University
13:55-14:20Multiscale   Computation and Simulation of Complex Molecular SystemsLI   GuohuiLiaoning Normal University
14:20-14:35Toward   Sense of Smell: Evolution-Based Classification of Olfactory Receptors WU   YiranZHAO Suwen Lab, ShanghaiTech University
14:35-14:50Activation Mechanism   Study and Agonist Design of STING ProteinLI   RuiZHANG Jian Lab, Shanghai Jiao Tong University
14:50-15:05PhenoScreen:   A Phenotypic Screening Method Established by a Dual-space Contrastive   Learning Framework for Linking Chemical Perturbations to Cellular   Morphological ProfilesWANG   ShihangBAI Fang Lab, ShanghaiTech University
15:05-15:20Unraveling   Disentangled Representations for Structural Heterogeneity in Cryo-EM using   Neural NetworksYU   BingIntegrative Biology Lab, ShanghaiTech University
15:20-15:35 Coffee Break
15:35-16:00Exploration   of New Targeted Protein Degradation TechnologiesLU   BoxunFudan   University
16:00-16:15A   multi-tissue cell membrane protein atlas reveals GPCRome remodeling in   response to obesity    LANG   XiaoyuSHUI Wenqing Lab, ShanghaiTech University
16:15-16:30Deciphering   Cell-specific Enhancers in the Cochlea for Efficient and Targeted Gene   Therapy of Hereditary Hearing LossZHAO   SimenZHONG Guisheng Lab, ShanghaiTech University
16:30-16:45Medial   Septum Contributions to Trajectory Encoding in the HippocampusLI   RuiZHOU Ning Lab, ShanghaiTech University
16:45-17:45Poster   Session 

Session III｜In Situ Structural Biology｜Chairs: Kurt Wüthrich, Wolfgang Baumeister & ZHANG Xiaojie
November 9
9:00-9:25Laser phased plate in cryo-EM Holger MuellerUniversity of   California, Berkeley
9:25-9:50Towards A CryoEM Foundation ModelYU   JingyiShanghaiTech   University
9:50-10:15In situ organization and dynamics inside neuronal synapseBI   GuoqiangUniversity   of Science and Technology of China
10:15-10:30 Coffee Break
10:30-10:55In-cell   NMR Spectroscopy for Cellular Structural BiologyLI   Conggang Innovation Academy for Precision Measurement   Science and Technology, CAS
10:55-11:153D   classification by AI for in situ subtomogram averaging of membrane-bridging   complexesVladan Lucic Max Planck   Institute of Biochemistry
11:15-11:35In-cell   structural insights into the sperm axoneme related asthenozoospermiaZHU   YunInstitute   of Biophysics, CAS
11:35-11:55Large-scale   analysis of protein conformations and interactions in live cell by CXMSZHAO   QunDalian   Institute of Chemical Physics, CAS
11:55-13:30 Lunch Break

Session II, Part 2｜Target Mechanism & Drug Discovery｜Chairs: XU Fei & SHUI Wenqing
November 9
13:30-13:55Developing Small Molecule   Agonists for GLP-1R and other Peptide GPCRsSONG XianqiangStructure Therapeutics
13:55-14:10Structure-guided   discovery of bile acid derivatives for treating, liver diseases without   causing itchYANG JunLEI Xiaoguang   Lab, Peking University
14:10-14:25Structure-based   discovery of selective 5-HT2A agonistsLI  HuiqiongCHENG   Jianjun Lab, ShanghaiTech University
14:25-14:50Cryo-EM in   translational science and pharma Eric ChenThermo Fisher   Scientific
14:50-15:05 Coffee Break
15:05-15:45Flash Talks for Poster Awards  | Host: ZHAO Suwen
15:45-15:55Poster Awards & Volunteer Appreciation
15:55-16:00Closing Remarks

Speakers

Invited speakers

(In alphabetical order by last name)

BI GuoqiangUniversity of Science and Technology of China
Eric Chen Thermo Fisher Scientific
LI ConggangInnovation Academy for Precision Measurement Science and Technology, CAS
LU BoxunFudan University 
Vladan LucicMax Planck Institute of Biochemistry
Holger  MuellerUniversity of California, Berkeley
SHAN YibingShanghaiTech University 
SONG XiangqiangStructure Therapeutics
XIE XinShanghai Institute of Materia Medica, CAS 
YU JingyiShanghaiTech University
ZHAO YanInstitute of Biophycics, CAS


Young Scholar Speakers

(In alphabetical order by last name)

LIN ShulingShanghai Institute of Materia Medica, CAS 
WANG YueShanghai Institute of Materia Medica, CAS
ZHAO QunDalian Institute of Chemical Physics, CAS
ZHU YunInstitute of Biophysics, CAS


    The Forum also features a series of short talks given by young scholars or students from different research groups at ShanghaiTech Univeristy or Shanghai Jiao Tong Univeristy.

Contact us

Contact Person: Dr. Feng (Ms.)

Phone: +86 021 20684420

Email: ihuman-forum@shanghaitech.edu.cn



Accommodation

本次会议不提供住宿预定，住宿及交通费用需自理，以下为会场附近酒店信息，如需请直接联系酒店。

雅乐轩酒店
上海市 浦东新区 张江高科技园区 海科路555号
电话：+86-21-3816 8888

如意智慧酒店
上海市 浦东新区 张江高科技园区 科苑路1500号
电话：+86-21-6165 1111

旅笼温泉假日酒店
上海市 浦东新区 金科路4395号

张江智选假日酒店
上海市 浦东新区 海科路777号

上海浦东嘉里大酒店
上海市浦东新区花木路1388号
电话：+86-21-6169 8888





Venue

Conference Center, ShanghaiTech University

Address: 1 Zhongke Road, Pudong New District, Shanghai, China

https://map.shanghaitech.edu.cn/